CBD and Stress

Peer-reviewed studies into the potential effects of Cannabidiol and Stress

On this page, CBD and Stress, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Stress. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Stress.

Endogenous cannabinoid signaling is essential for stress adaptation.

From the abstract:

The present findings demonstrate an important role for endocannabinoid signaling in the process of stress [hypothalamic-pituitary-adrenal axis] habituation, and suggest that [anandamide] and 2-AG modulate different components of the adrenocortical response to repeated stressor exposure.

Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

From the abstract:

The endocannabinoid system is a widely distributed, neuromodulatory system which serves an integral role in regulating synaptic transmission. The presence of this system in stress-responsive neural circuits suggests that it may play a critical role in regulating neuroendocrine and behavioral responses to stress… Therapeutically, these data suggest that the endocannabinoid system could be dysregulated in affective disorders, such as depression, which are characterized by maladaptive stress coping. In this review, we discuss the evidence demonstrating that the endocannabinoid system is affected by and can oppose the effects of prolonged stress and, as such, represents a potential target for the development of novel antidepressant agents.

Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output. 

From the abstract:

The presence of endocannabinoid signaling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of stress. The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress… Collectively, these data demonstrate the importance of endocannabinoid signaling at multiple levels as both a regulator and an effector of the stress response.

Neuromodulators, stress and plasticity: a role for endocannabinoid signalling.

From the abstract:

Our recent findings, however, indicate that repeated homotypic stress in rats causes functional changes in neural circuitry in the hypothalamus. In particular, we focus on signalling via endocannabinoids and describe plasticity in this system that impacts fast retrograde signalling at synapses on to the stress command neurons in the brain. Interestingly, this plasticity appears to be limited to early adolescence, hinting at unique modes of control of neural circuits by stress during different developmental stages.

Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress.

From the abstract:

Here, we investigated whether alterations in eCB signaling might contribute to the cognitive impairments induced by chronic stress… data suggest that stress-induced downregulation of hippocampal eCB signaling contributes to problems in behavioral flexibility and could play a role in the development of perseveratory and ruminatory behaviors in stress-related neuropsychiatric disorders.

Endocannabinoids and stress.

From the abstract:

Endogenous cannabinoids play an important role in the physiology and behavioral expression of stress responses. Activation of the hypothalamic-pituitary-adrenal (HPA) axis, including the release of glucocorticoids, is the fundamental hormonal response to stress. Endocannabinoid (eCB) signaling serves to maintain HPA-axis homeostasis, by buffering basal activity as well as by mediating glucocorticoid fast feedback mechanisms… Investigation into the role of the eCB system in allostatic states and recovery processes may give insight into possible therapeutic manipulations of the system in treating chronic stress-related conditions in humans.

Stress regulates endocannabinoid-CB1 receptor signaling. 

From the abstract:

 Chronic variable stress exposure reduces endocannabinoid-CB1 receptor signaling and it is hypothesized that the resultant deficiency in endocannabinoid signaling contributes to the negative consequences of chronic stress. On the other hand, repeated exposure to the same stress can sensitize CB1 receptor signaling, resulting in dampening of the stress response. Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endocannabinoid/CB1 receptor signaling provides resilience against the development of stress-related pathologies.

Chronic stress impairs alpha1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus. 

From the abstract:

Collectively, these results indicate that chronic restraint stress impairs the [alpha 1-adrenergic receptor] [long term depression] by reducing the function of presynaptic CB1 receptors and reveal a novel mechanism by which noradrenaline controls synaptic strength and plasticity in the DRn. They also provide evidence that chronic stress impairs [endocannabinoid] signaling in the [dorsal raphe nucleus], which may contribute, at least in part, to the dysregulation of the stress homeostasis.

Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance.

From the abstract:

While the acute stress response has essential survival value, chronic stress and dysfunction of the stress response can be maladaptive, contributing to the development and severity of psychiatric and pain disorders. The endogenous cannabinoid (endocannabinoid) system has emerged as an important lipid signalling system playing a key role in mediating and/or modulating behavioural, neurochemical, neuroendocrine, neuroimmune and molecular responses to stress.

Cannabidoid receptor activaiton prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression.

From the abstract:

Our results show that [chronic mild stress] significantly modified physiological and behavioral reactions, as observed by the impairment in avoidance extinction and [long-term potentiation] in the hippocampal-accumbens pathway, and the alterations in depression-like symptoms, such as coping with stress behavior, weight gain, and sucrose consumption. The most significant effect observed in this study was that 3 days of [CB1/2 receptor agonist] administration prevented the CMS-induced alterations in emotional memory (ie, extinction) and plasticity.

Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory.

From the abstract:

Chronic WIN55,212-2 (CB1/2 receptor agonist) administration prevented the stress-induced impairment in LTP levels and in the spatial task, with no effect on stress-induced alterations in unconditioned anxiety levels or GR levels… Our findings suggest that cannabinoid receptor activation could represent a novel approach to the treatment of cognitive deficits that accompany a variety of stress-related neuropsychiatric disorders.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

From the abstract:

Cannabidiol (CBD), the main non-psychotomimetic component of the plant Cannabis sativa, exerts therapeutically promising effects on human mental health such as inhibition of psychosis, anxiety and depression. However, the mechanistic bases of CBD action are unclear. Here we investigate the potential involvement of hippocampal neurogenesis in the anxiolytic effect of CBD in mice subjected to 14 d chronic unpredictable stress (CUS)… findings support that the anxiolytic effect of chronic CBD administration in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signalling.

Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid.

From the abstract:

The nucleus accumbens (NAc), a major component of the mesolimbic system, is involved in the mediation of reinforcing and addictive properties of many dependence-producing drugs. Glutamatergic synapses within the NAc can express plasticity, including a form of endocannabinoid (eCB)-long-term depression (LTD). Recent evidences demonstrate cross talk between eCB signaling pathways and those of other receptor systems..