CBD and Sleep Disorders

Peer-reviewed studies into the potential effects of Cannabidiol and Sleep Disorders

On this page, CBD and Sleep Disorders, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Sleep Disorders. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Sleep Disorders.

The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent.

From the abstract:

 Here, the authors report that when administered 10 or 20 microg/1 microl during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep… These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine.

From the abstract:

Sleep-laboratory results indicate a mild activating effect of CBD, and slight residual sedation with THC-predominant extracts. Experience to date with Sativex (1:1 THC:CBD) in numerous Phase I-III studies in 2000 subjects with 1000 patient years of exposure demonstrate marked improvement in subjective sleep parameters in patients with a wide variety of pain conditions…

Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats.  

From the abstract:

The systemic acute administration of CBD appears to increase total sleeptime, in addition to increasing sleep latency in the light period of the day of administration.

Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults.

From the abstract:

The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied in 8 healthy volunteers (4 males, 4 females; 21 to 34 years)… Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC. 

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.

From the abstract:

In conclusion, we found that CBD modulates waking via activation of neurons in the hypothalamus and DRD. Both regions are apparently involved in the generation of alertness. Also, CBD increases DA levels as measured by microdialysis and HPLC procedures. Since CBD induces alertness, it might be of therapeutic value in sleep disorders such as excessive somnolence.

Endocannabinoid modulation of cortical up-states and NREM sleep.

From the abstract:

We hypothesized that the endocannabinoid (EC) system, a neuromodulatory system intrinsic to the cortical microcircuitry, is an important regulator of up-states and sleep… findings demonstrate that the EC system actively regulates cortical up-states and important features of NREM sleep such as its duration and low frequency cortical oscillations.

Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat. 

From the abstract:

…data support the view that dronabinol stabilizes respiratory pattern and augments upper airway muscles by acting at the nodose ganglia. These findings underscore a therapeutic potential of dronabinol for the treatment of obstructive sleep apnea.

Endocannabinoid Signaling Regulates Sleep Stability. 

From the abstract:

The hypnogenic properties of cannabis have been recognized for centuries, but endogenous cannabinoid (endocannabinoid) regulation of vigilance states is poorly characterized… These results support the hypothesis that endocannabinoid signaling through CB1 is necessary for [non-rapid eye movement] stability but it is not necessary for sleep homeostasis.

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

From the abstract:

Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term. Novel studies investigating cannabinoids and obstructive sleep apnea suggest that synthetic cannabinoids such as nabilone and dronabinol may have short-term benefit for sleep apnea due to their modulatory effects on serotonin-mediated apneas. CBD may hold promise for REM sleep behavior disorder and excessive daytime sleepiness, while nabilone may reduce nightmares associated with PTSD and may improve sleep among patients with chronic pain.

Effectiveness of Cannabidiol Oil for Pediatric Anciety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.

From the abstract:

Cannabidiol oil, an increasingly popular treatment of anxiety and sleep issues, has been documented as being an effective alternative to pharmaceutical medications. This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.