CBD and Migraines

Peer-reviewed studies into the potential effects of Cannabidiol and Migraines

On this page, CBD and Migraines, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Migraines. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Migraines.


Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

From the abstract:

Migraine, fibromyalgia, IBS and related conditions display common clinical, biochemical and pathophysiological patterns that suggest an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines.

Effects of anandamide in migraine: data from an animal model.

From the abstract:

The study confirms that a dysfunction of the endocannabinoid system may contribute to the development of migraine attacks and that a pharmacological modulation of CB receptors can be useful for the treatment of migraine pain.

Cannabinoids and hallucinogens for headache.

From the abstract:

Cannabinoids in particular have a long history of use in the abortive and prophylactic treatment of migraine before prohibition and are still used by patients as a migraine abortive in particular.

The endocannabinoid system and migraine.

From the abstract:

In this review we shall describe experimental and clinical data that, intriguingly, demonstrate the link between endocannabinoids and migraine, a neurovascular disorder characterized by recurrent episodic headaches and caused by abnormal processing of sensory information due to peripheral and/or central sensitization. Although the exact ECS-dependent mechanisms underlying migraine are not fully understood, the available results strongly suggest that activation of ECS could represent a promising therapeutical tool for reducing both the physiological and inflammatory components of pain that are likely involved in migraine attacks.

Variations in the cannabinoid receptor 1 gene predispose to migraine. 

From the abstract:results suggest a significant effect of [CB1 gene] on migraine headaches that might be related to the alteration of peripheral trigeminovascular activation.

Cannabinoids suitable for migraine prevention 

From the article:

A study has confirmed that cannabinoids are just as suitable as a prophylaxis for migraine attacks as other pharmaceutical treatments.