CBD and Inflammation

Peer-reviewed studies into the potential effects of Cannabidiol and Inflammation

On this page, CBD and Inflammation, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Inflammation. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Inflammation.

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

From the abstract:

Oxidative stress with reactive oxygen species generation is a key weapon in the arsenal of the immune system for fighting invading pathogens and initiating tissue repair. If excessive or unresolved, however, immune-related oxidative stress can initiate further increasing levels of oxidative stress that cause organ damage and dysfunction…. growing evidence suggests that the endocannabnoid system, which includes the CB1 and CB2 G-protein-coupled receptors and their endogenous lipid ligands, may be an area that is ripe for therapeutic exploitation… cannabidiol, which may interact with the endocannabinoid system but has actions that are distinct offers promis as a prototype for anti-inflammatory drug development.

The endocannabinoid system: an emerging key plater in inflammation.

From the abstract:

The purpose of this review is to illustrate the expanding view of the endocannabinoid system (ECS) in realtion to its roles in inflammation… This endocannabinoidome continues to offer possibilities for prevention and intervention…

Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice.  

From the abstract:

The anti-inflammatory effects of O-1602 and cannabidiol (CBD), the ligands of G protein-coupled receptor 55 (GPR55), onn experimental acute pancreatitis (AP) were investigated… Cannabidiol and )-1602 showed anti-inflammatory effects in mice with AP and improved the expression of GPR55 in the pancreatic tissue as well.

Cannabinoids, endocannabinoids, and related analogs in inflammation.

From the abstract:

This review covers reports published in the last 5 years on the anti-inflammatory activities of all classes of cannabinoids, including phytocannabinoids such as tetrahydrocannabinol and cannabidiol… A possible mechanism for these actions is suggested involving increased production of eicosanoids that promote the resolution of inflammation. This differentiates these cannabinoids from cyclooxygenase-2 inhibitors that suppress the synthesis of eicosanoids that promor the induction of the inflammatory process.

Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acut lung injury: role for the adenosine A(2A) receptor.

From the abstract:

… we show that cannabidiol has anti-inflammatory effects in a murine model of acute lung injury and that this effect is most likely associated with an increase in the extracellular adenosine offer and signaling through adenosine A(2A) recepror.

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

From the abstract:

This review is focused on the therapeutic effects of cannabidiol (CBD), a non-psychoactive native cannabinoid, as an emerging and novel therapeutic modality in ophthalmology based on systematic sstudies in animal models of inflammatory retinal diseases including diabetic retinopathy-a retinal disease associated with vascular-neuroinflammation. Special emphasis is placed on novel mechanisms which may shed light on the pharmacological acitivity associated with CBD preclinically.

Cannabinoids suppresss inflammatory and neuropathic pain by targeting alpha3 glycine receptors 

From the abstract:

We report that systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivitaves significantly suppress chronic inflammatory and neuropathic pain without causing apparent analegesic tolerance in rodents.

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. 

From the abstract:

[Cannabidiol] reduced the expression of S100B and iNOS proteins in the human biopsies confirming its well documented effect in septic mice… CBD targets enteric reactive gliosis, counteracts the inflammatory environment induced by LPS in mice and in human colonic cultures derived from [ulcerative colitis] patients. These actions lead to a reduction of intestinal damage mediated by PPARgamma receptor pathway. Our results therefore indicate that CBD indeed unravels a new therapeuric strategy to treat inflammatory bowel diseases.

The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications.

From the abstract:

Oxidative stress and inflammation play critical roles in the development of diabetes and its complications… This review focuses on the role of the endocannabinoid system in primary diabetes and its effects on various diabetic complications, such as diabetic cardiovascular dysfunction, nephropathy, retinopathy, and neuropathy… The therapeutic potential of targeting the endocannabinoid system and certain plant-derived cannabinoids, such as cannabidiol… in diabetes and diabetic complications is also discussed.

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barier disruption

From the abstract:

Since a disruption of the endothelial function and integrity by HG is a crucial early event underlying the development of various diabetic complications, our results suggest that CBD, which has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in humans, may have significant therapeutic benefits against diabetic complications and atherosclerosis.

Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

From the abstract:

 We examined whether the CBD antihyperalgesic effect could be mediated by cannabinoid receptor type 1 (CB1) or cannabinoid receptor type 2 (CB2) and/or by transient receptor potential vanilloid type 1 (TRPV1)… results demonstrate that TRPV1 receptor could be a molecular target of the CBD antihyperalgesic action.

*Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death.*

From the abstract:

The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use… Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function. Thus, our results suggest that cannabidiol may represent a promising new protective strategy against cisplatin-induced nephrotoxicity.

Cannabinoids in clinical practice

From the abstract:

CBD and CBG also have analgesic and antiinflammatory effects, indicating that there is scope for developing drugs which do not have the psychoactive properties of THC.

Cannabinoids, inflammation, and fibrosis

From the abstract:

Cannabinoids (including CBD) apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects associated with NSAIDs. Their clinical development thus provides a new approach to treatment of diseases characterized by acute and chronic inflammation and fibrosis.

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

From the abstract:

The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons… data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

Protective effect of cannabidiol on hydrogen peroxide-induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells.

From the abstract:

Cannabidiol, a major component of marijuana, protects nerves, and exerts antispasmodic, anti-inflammatory and anti‑anxiety effects. In the current study, the protective effect of cannabidiol was observed to prevent hydrogen peroxide (H2O2)‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells… results suggest that cannabidiol potentially exerts its protective effect on LDH via the suppression of anti‑apoptosis, anti‑inflammation and anti‑oxidative activities in nucleus pulposus cells.

Mechanisms of action of cannabidiol in adoptively transferred experimental autoimmune encephalomyelitis.

From the abstract:

…CBD markedly improved the clinical signs of at-EAE and reduced infiltration, demyelination and axonal damage. The CBD-mediated decrease in the viability of encephalitogenic cells involves ROS generation, apoptosis and a decrease in IL-6 production and may contribute to the therapeutic effect of this compound.