CBD and Heart Disease

Peer-reviewed studies into the potential effects of Cannabidiol and Heart Disease

On this page, CBD and Heart Disease, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Heart Disease The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Heart Disease. If you have any questions pertaining to the research, please email us at info@hempicated.com.

17 Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors

From the abstract:

Cannabidiol (CBD) has been shown to be anti-arrhythmic (Walsh et al, 2010) and tissue sparing (Durst et al, 2007) in an in vivo rat model of coronary artery occlusion (CAO)… The observed synergism which persists when CB1 receptors are blocked prior to CBD administration, suggest cross-talk between CB1 and other CB receptors in the heart during ischaemia.

Is the cardiovascular system a therapeutic target for cannabidiol?

From the abstract:

In the heart, in vivo CBD treatment protects against ischaemia-reperfusion damage and against cardiomyopathy associated with dabetes.. Similarly, in a different model of ischaemia-reperfusion, CBD has been shown to reduce infarct size and inrease blood flow in animal models of stroke… Taken together, these preclinical data appear to support a positive role for CBD treatment in the heart, and in peripheral and cerebral vasculature…

Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion

From the abstract:

This study demonstrates that CBD is cardioprotective in the acute phase of [ischaemia and reperfusion] by both reducing ventricular arrhythmias and attenuating infarct size. The anti-arrhythmic effect, but not the tissue sparing effect, may be mediated through an inhibitory effect on platelet activation.

The Effect of Cannabidiol on Ischemia/Reperfusion -Induced Ventricular Arrhythmias

From the abstract:

Cannabidiol treatment significantly decreased the incidence and the duration of ventricular tachycardia, total length of arrhythmias, and the arrhythmia scores compared to control during the reperfusion period… The present results demonstrated that CBD has an antiarrhythmic effect against I/R-induced arrhythmias, and the antiarrhythmic effect of CBD may be mediated through the activation of adenosine A1 receptor.

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy.

From the abstract:

Collectively, these results coupled with the excellent safety and tolerability profile of CBD in humans, strongly suffest that it may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovasular disorders, by attenuating oxidative/nitrative stress, inflammation, cell death and fibrosis.

Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis

From the abstract:

Doxorubicin (DOX) is a widely used, potent chemotherapeutic agent; however, its clinical application is limited because of its dose-dependent cardiotoxicity… Treatment with CBD markedly improved DOX-induced cardiac dysfunction, oxodative/nitritive stress and cell death. CBD also enhanced the DOX-induced impaited cardiac mitochondrial function and biogenesis. These data suggest that CBD may represent a novel cardioprotective strategy against DOX-induced cardiotoxicity…

Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? 

From the abstract:

Oleamide (cis-9, 10-octadecenoamide), a fatty acid primary amide… has a variety of actions that give it potential as a signaling molecule… Oleamide interacts with voltage-gated Na(+) channels and allosterically with GABA(A) and 5-HT(7) receptors as well as having cannabinoid-like actions. The latter have been suggested to be due to potentiation of the effects of endocannabinoids such as anandamide by inhibiting FAAH-mediated hydrolysis. However, oleamide has direct agonist actions at CB(1) cannabinoid receptors and also activates the TRPV1 vanilloid receptor. Other actions include inhibition of gap-junctional communication, and this might give oleamide a role in myocardial development.

Endocannabinoids Acting at Cannabidoid-1 Receptors Regulate Cardiovascular Function in Hypertension

From the abstract:

We conclude that endocannabinoids tonically suppress cardiac contractility in hypertension and that enhancing the CB1-mediated cardiodepressor and vasodilator effects of endogenous anandamide by blocking its hydrolysis can normalize blood pressure Targeting the endocannabinoid system offers novel therapeutic strategies in the treatment of hypertension.

Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

From the abstract:

Our study shows that CBD induces a substantial in vivo cardioprotective effect from ischemia that is not observed ex vivo. Inasmuch as CBD has previously been administered to humans without causing side effects, it may represent a promising novel treatment for myocardial ischemia