CBD and Diabetes

Peer-reviewed studies into the potential effects of Cannabidiol and Diabetes

On this page, CBD and Diabetes, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Diabetes The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Diabetes. If you have any questions pertaining to the research, please email us at info@hempicated.com.

The Impact of Marijuana Use on Glucose, Insulin, and Insulin Restance among US Adults

From the abstract:

…current marijuana use was associated with 16{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a} lower fasting insulin levels… and 17{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a} lower [homeostasis model assessment of insulin resistance]. We found significant associations between marijuana use ans smaller waist circumferences.

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy 

From the abstract:

CBD attenuated myocardial dysfunction, cardiac fibrosis, oxidative/nitrative stress, inflammation, cell death, and interrelated signaling pathways. Furthermore, CBD also attenuated the high glucose-induced increased reactive oxygen species generation, nuclear facro-kB activation, and cell deat in primary human cardiomycytes… Collectively, these results coupled with the excellent safety and tolerability profile of CBD in humans, strongly suggest that it may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovasculat disorders…

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice  

From the abstract:

We now report that [cannabidiol] treatment significantly reduces the incidence of diabetes in [non-obese diabetes-prone] mice from an incidence of 86{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a} in non-treated control mice to an incidence of 30{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a} in CBD-treated mice… Our results indicate that CBD can inhibit and delay destructive insulitis and inflammatory Th1-associated cytokine production…

Neuroptotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes

From the abstract:

Diabetic retinopathy is characterized by blood-retinal barrier (BRB) breakdown and neurotoxicity… [Cannabidiol (CBD)] treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor-alpha, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina. Consistent with these effects, CBD treatment also significantly inhibited p38 MAP kinase in teh diabetic retina. These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals through activities that may involve inhibtion of p38 MAP kinase.

Cannabidiol aressts onset of autoimmune diabetes in NOD mice

From the abstract:

We have previously reported that cannabidiol (CBD) lowers the incidence of diabetes in young non-obese diabetes-prone (NOD) female mice. In the present study we show that administration of CBD to 11-14 week old female NOD mice, which are either in a latent diabetes stage or with initial symptoms of diabetes, ameliorates the manifestations of the disease… Our data stregnthen our previous assumption that CBD, known to be safe in man, can possibly be used as a therapeutic agent for the treatment of type 1 diabetes.

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

From the abstract:

This review is focused on the therapeutic effects of cannabidiol (CBD), a non-psychoactive native cannabinoid, as an emerging and novel therapeutic modality in ophthalmology based on systematic sstudies in animal models of inflammatory retinal diseases including diabetic retinopathy-a retinal disease associated with vascular-neuroinflammation. Special emphasis is placed on novel mechanisms which may shed light on the pharmacological acitivity associated with CBD preclinically.

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes 

From the abstract:

…evidence is emerging that some nonpsychotropic plant cannabinoids, such as cannabidiol, can be employed to retard beta-cell damage in type 1 diabetes. 

Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes  

From the abstract:

Cannabidiol incubation improved acetylcholine responses in the arteries of Zucker Diabetic Fatty rats (aorta and femoral) and Zucker lean (aorta, femoral and G3 mesenteric), and this effects was greater in the Zucker Diabetic Fatty rat. These studies suggest that increased circulating endocannabinoids may alter vascular function both positively and negatively in type 2 diabetes, and that part of the beneficial effect of cannabidiol in diabetes may be due to improved endothelium-dependant vasorelaxation 

The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications.

From the abstract:

Oxidative stress and inflammation play critical roles in the development of diabetes and its complications… This review focuses on the role of the endocannabinoid system in primary diabetes and its effects on various diabetic complications, such as diabetic cardiovascular dysfunction, nephropathy, retinopathy, and neuropathy… The therapeutic potential of targeting the endocannabinoid system and certain plant-derived cannabinoids, such as cannabidiol… in diabetes and diabetic complications is also discussed.

Cannabinoid-Mediated Modulation of Neuropathic Pain and Microglial Accumulation in a Model of Muring Type 1 Diabetic Peripheral Neuropathic Pain

From the abstract:

The prevention of microglial accumulation and activation in the dorsal spinal cord was associated with limited development of a neuropathic pain state. Cannabinoids demostrated antinociceptive effects in this mouse model of [diabetic peripheral neuropathy]. These results suggest that such interventions may also benefit humans with [diabetic peripheral neuropathy], and their early introduction may also modify the deelopment of the [neuropathic pain] state.

Biochemical and immunohistochemical changes in delta-9-tetrahydrocannabinol-treated type 2 diabetic rats

From the abstract:

…the area percent of glucagon immunoreactive cells showed a decrease in diabetic+delta9-THC rats compared to that of diabetic animals alone. Serum [total colesterol], HDL, and LDL levels of diabetes+delta9-THC group showed a decrease compared to the diabetic group. These results indicated that delta9-THC may serve a protective role against hyperlipidemia and hyperglycemia in diabetic rats.

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-controlled, Parallel Group Pilot Study

From the abstract:

Cannabidiol (CBD) and delta9-tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids affecting lipid and glucose metabolism in animal models… Compared with baseline (but not placebo), CBD decreased resistin (-898 pg/ml; P < 0.05) and increased glucose-dependent insulonotropic peptide (21.9 pg/ml; P< 0.05)…

Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barier disruption

From the abstract:

Since a disruption of the endothelial function and integrity by HG is a crucial early event underlying the development of various diabetic complications, our results suggest that CBD, which has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in humans, may have significant therapeutic benefits against diabetic complications and atherosclerosis.