CBD and Anxiety

Peer-reviewed studies into the potential effects of Cannabidiol and Anxiety

On this page, CBD and Anxiety, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Anxiety. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Anxiety. If you have any questions pertaining to the research, please email us at info@hempicated.com.

Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

From the abstract:

Studies using animal models of anxiety and involving healthy volunteers clearly suggest an anxiolytic-like effect of CBD. Moreover, CBD was shown to reduce anxiety in patients with social anxiety disorder.

Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.

From the abstract:

…a variety of experiments on [anxiety and depression], such as the forced swimming test (FST), elevated plus maze (EPM) and VOgel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models…

Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients 

From the abstract:

Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significanly decreased alert in their anticipatory speech.

Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.  

From the abstract:

Relative to placebo, CBD was associated with significantly decreased subjective anxiety (p<0.001), reduced ECD uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus (p<0.001, uncorrected), and increased ECD uptakein in the right posterior cingulate gyrus… These results suggest that CBD reduces anxiety in SAD and that this is related to its effects on activity in the limbic and paralimbic brain areas.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

From the abstract:

CBD administration prevented the anxiogenic effect of [chronic unpredictable stress] in wild type but not GFAP-TK mice as evidenced in the novelty suppressed feeding test and the elevated plus maze. This anxiolytic effect of CBD involved the participation of the CB1 cannabinoid receptor…

Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentaion

From the abstract:

Pharmacological augmentation of central endogenous cannabinoid (eCB) signaling may be an effective therapeutic strategy to mitigate the adverse behavioral and physiological consequences of stress.

Effects of Cannabidiol (CBD) on Regional Cerebral Blood Flow

From the abstract:

CBD significantly decreased subjective anxiety and increased mental sedation, while placebo did not induce significant changes… These results suggest that CBD has anxiolytic properties, and that these effects are mediated by an action on limbic and paralimbic brain areas.

The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors 

From the abstract:

CBD increased open arms expoloration in the [elevated plus-maze] as well as the number of punished licks in the [Vogel conflict test], suggesting an anxiolytic-like effect. The drug did not change the number of entries into the closed arms of the [elevated plus-maze] nor interfered with water consumption or nociceptive threshold, discarding potential confounding factors in the two test.

A Systematic Review of Plant-Derived Natural Compounds for Anxiety Disorders

From the abstract:

Results showed that phyrochemicals like; alkaloids, flavonoids, phenolic acids, lignans, cinnamates, terpenes and saponins posses aniolytic effects in a wide range of animal models of anxiety. The involved mechanisms include interaction with [GABA} receptors… serotonergic 5-hydrodytryptamine (5-HT1A) and 5-HT2A/C… as well as cannabinoid (CB)1 and CB2 receptors.

Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence  

From the abstract:

The therapeutic application of psychotropic plant-based treatments for axiety disorders is also discussed, specifically… cannabidiol-enriched (low tetrahydrocannabinol (delta9-THC)) Cannabis spp.

The Endocannabinoid System and Anxiety

From the abstract:

Cannabinoids and [endocannabinoid] system often exert opposite effects on several functions, such as anxiety… recent advances in research about the relationship between [endocannabinoid] system and anxiety disorders in humans, as well as in animal models, will be discussed.

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

From the abstract:

There is also accumulating evidence from animal studies investigating the effects of cannabidiol on fear memory processing indicating that it reduces learned fear in paradigms that are translationally relevant to phobias and post-traumatic stress disorder. Cannabidiol does so by reducing fear expression acutely and by disrupting fear memore reconsolidation and enhancing fear extinction, both of which can reuls in lasting reduction of learned fear.

Effect of prior foot shock stress and delta9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats.

From the abstract:

In the absence of the esplicit [foot shock] stressor… CBDA produced neither anxiogenic- nor anxiolytic-like responding…administration of CBDA or CBD prevented the [foot shock]-induced anxiogenic-like responding (an anxiolytic-like effect)… These results suggest the anxiolytic effects of CBDA and CBD may require the presence of a specific stressor.

Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report

From the abstract:

A trial of cannabidiol oil resulted in a maintained decrease in anxiety and a steady improvement in the quality and quantity of the patient’s sleep… This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.

Cannibidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults

From the abstract:

These findings indicate that CBD has minimal behavioral and subjective effects in healthy volunteers, even when they are presented with emotional stimuli.