CBD and Addiction

Peer-reviewed studies into the potential effects of Cannabidiol and Addiction

On this page, CBD and Addiction, you will find research pertaining to the use of Cannabidiol and Cannabinoids and its possible effects on Addiction. The information below is not meant to influence your opinion, but rather give you access to a wealth of scientific literature in an attempt to make and educated and informed choice. Click Here to see all of the conditions that have been researched alongside CBD and Addiction. If you have any questions pertaining to the research, please email us at info@hempicated.com.

Cannabidiol as an Intervention for Addictive Behaviors

From the abstract:

Cannabidiol (CBD), the second most abundant component of cannabis, is thought to modulate various neuronal circuits involved in drug addiction… preclinical studies suggest that CBD may have therapeutic properites on opiod, cocaine, and psychostimulant addiction

Cannabinoids for the treatment of dementia

From the abstract:

There is increasing evidence that the cannabinoid system may regulate neurodegenerative processes such as excessive glutamate production, oxidative stress and neuroinflammation. Neurodegeneration is a feature common to the various types of dementia and this has led to interest in whether cannabinoids may be clinically useful in the treatment of people with dementia.

Cannabidiol reduces cigarette consumption in tobacco smokers: Preliminary findings

From the abstract:

Over the treatment week, placebo treated smokers showed no differences in number of cigarettes smoked. In contrast, those treated with CBD significantly redued the number of cigarettes smoked by ~40{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a} during treatment… These preliminary data, combined with the strong preclinical rationale for use of this compound, suggest CBD to be a potential treatment for nicotine addiction that warrants further exploration.

Inhibition of monoacylglycerol lipase reduces nicotine withdrawal

From the abstract:

The MAGL inhibitor, JZL184, dose-dependaently reduced somatic and aversive withdrawal signs, which was blocked by rimonabant, indicating a CB1 receptor-dependent mechanism.

Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances

From the abstract:

The findings highlight the unique contributions of distinct cannabis constituents to addiction vulnerability and suggest that CBD may be a potential treatment for heroin craving and relapse.

Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT1A receptors in the dorsal raphe nucleus

From the abstract:

Our results suggest that cannabidiol interferes with brain reward mechanisms responsible for the expression of the acute reinforcing properties of opioids, thus indicating that cannabidiol may be clinically useful in attenuating the rewarding effects of opioids.

Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

From the abstract:

Data illustrate differences between psychoinactive cannabinoids in their interation with delta 9-THC that might be relevant to possible cliniscal use of Cannabis in narcotic detoxification. 

Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment

From the abstract:

Pilot data also suggested that objective ratings of opiate withdrawal decrease in [methadone maintenance treatment] patients using cannabis during stabilization… The present findings may point to novel interventions to be employed during treatment for opiate dependence that specifically target cannabinoid-opioid system interations. 

Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

From the abstract:

Medicalcannabis laws are associated with significantly lower state-levelopioid overdose mortality rates. 

Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents

From the abstract:

The main results indicate that in cocaine addicts, but not in mixed cocaine/opiate or opiate abusers, CB1 recaptor protein in the prefrontal cortex (PFC) was reduced (-44{03c6ed9c7292793a5635106886a6facae0686a7e7bfbe6c29280aa83fc7d030a}, total homogenate)… the antagonists rimonabant and AM281 induced opposite effects (receptor upregulation in membranes and cytosol).

Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity.

From the abstract:

When administered concurrently with binge ethanol exposure, CBD protected against hippocampal and entorhinal cortical neurodegeneration in a dose-dependant manner… (which) provides the first demonstration of CBD as an in vivo neuroprotectant…

Transdermal delivery of cannabidiol attenutates binge alcohol-induced neurodegenration in a rodent model of an alcohol use disorder

From the abstract:

…results demonstrate the feasibility of using CBD transdermal delivery systems for the treatment of alcohol-induced neurodegeneration.

Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report

From the abstract:

Daily symptom assessments demonstrated the absence of significant withdrawal, anxiety and dissociative symptoms during the treatment.

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders

From the abstract:

Recent studies have also begun to elucidate the effects of cannabidiol on drug memory expression using paradigms with translational relevance to addiction. The findings suggest that cannabidiol reduces the expression of drug memories acutely and by disrupting their reconsolidation.

Early Phase in the Develpment of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage

From the abstract:

Our paper provides an overview of preclinical animal and human clinical investigations, and presents preliminary clinical data that collectively sets a strong foundation in supports of the further exploration of CBD as a therapeutic intervention against opioid relapse. 

Epigenetic mechanisms associated with addiction-related behavioural effects of nicotine and/or cocaine: implication of the endocannabinoid system

From the abstract:

On the basis of intense interactions with the target neurotransmitter systems, the endocannabinoid (ECB) system hass been considered pivotal for eliciting the effects of NC or COC.